Shelton Jackson "Spike" Lee is an American film director, producer, writer, and actor. His production company, 40 Acres and a Mule Filmworks, has produced over 35 films since 1983. Lee's movies have examined race relations, colorism in the black community, the role of media in contemporary life, urban crime and poverty, and other political issues. Lee has won numerous awards, including an Emmy Award. He has also received two Academy Award nominations; as well as winning the 2013 Gish Prize "for his brilliance and unwavering courage in using film to challenge conventional thinking. Spike Lee has traced his roots to Cameroon (on his father's side) and Niger (on his mother's side)

Donald Frank "Don" Cheadle, Jr is an American actor and producer. In 2004, his lead role as Rwandan hotel manager Paul Rusesabagina in the genocide drama film Hotel Rwanda, which was set during the Rwandan Genocide earned him a nomination for an Academy Award for Best Actor. He also campaigns for the end of genocide in Darfur, Sudan, and co-authored, with John Prendergast, a book concerning the issue entitled Not On Our Watch: The Mission to End Genocide in Darfur and Beyond. Along with George Clooney, Brad Pitt, Matt Damon, David Pressman, and Jerry Weintraub, Cheadle co-founded the Not on Our Watch Project, an organization focusing global attention and resources to stop and prevent mass atrocities. In 2010, Cheadle was named U.N. Environment Program Goodwill Ambassador. According to a DNA test, some of Don’s ancestry is Cameroonian.

Oprah Gail Winfrey is an American media proprietor, talk show host, actress, producer, and philanthropist. Winfrey is best known for her multi-award-winning talk show The Oprah Winfrey Show which was the highest-rated program of its kind in history and was nationally syndicated from 1986 to 2011. Dubbed the "Queen of All Media", she has been ranked the richest African-American of the 20th century, the greatest black philanthropist in American history, and is currently North America's only black billionaire. She is also, according to some assessments, the most influential woman in the world. In 2013, she was awarded the Presidential Medal of Freedom by President Barack Obama and an honorary doctorate degree from Harvard. A DNA test did trace Oprah's maternal line back to the Bamileke people of Cameroon.

Blair Erwin Underwood is an American television, film, and stage actor and director. He played headstrong attorney Jonathan Rollins on the NBC legal drama L.A. Law for seven years. He has received two Golden Globe Award nominations, three NAACP Image Awards and one Grammy Award. In recent years, he has appeared on The New Adventures of Old Christine, Dirty Sexy Money and In Treatment and was in NBC's The Event. Underwood's DNA test showed that he is a descendant of the Babungo people of Cameroon. Blair Underwood and his father went to Cameroon to visit the Tikar Village of Babungo and connect with their brothers.

Edward Regan "Eddie" Murphy is an American comedian, actor, writer, singer, director, and musician. Box-office takes from Murphy's films make him the fourth-highest grossing actor in the United States. He was a regular cast member on Saturday Night Live from 1980 to 1984 and has worked as a stand-up comedian. He was ranked no.10 on Comedy Central's list of the 100 Greatest Stand-ups of All Time. He has received Golden Globe Award nominations for his performances in 48 Hrs., Beverly Hills Cop series, Trading Places, and The Nutty Professor. In 2007, he won the Golden Globe for Best Supporting Actor and received a nomination for the Academy Award for Best Supporting Actor for his portrayal of soul singer James "Thunder" Early in Dreamgirls. He traces his African descent mainly to Cameroon.

Quincy Delight Jones, Jr. is an American record producer, conductor, arranger, composer, television producer, film producer, instrumentalist, magazine founder, record company executive, humanitarian, and jazz trumpeter. His career spans six decades in the entertainment industry and a record 79 Grammy Award nominations, 27 Grammys, including a Grammy Legend Award in 1991. In 1971, Jones was the first African American to be named as the musical director/conductor of the Academy Awards ceremony. In 1995 he was the first African American to receive the Academy's Jean Hersholt Humanitarian Award. He is tied with sound designer Willie D. Burton as the African American who has been nominated for the most Oscars; each has received seven nominations. Through his direct matrilineal line (mt DNA), he is of West African/Central African ancestry of Tikar descent, a people centered in present-day Cameroon and known for their music.

Christopher Julius "Chris" Rock III is an American comedian, actor, screenwriter, television producer, film producer, and director. He was voted as the fifth greatest stand-up comedian of all time by Comedy Central. A DNA test showed that he is descended from the Udeme people of northern Cameroon.

Joakim Simon Noah is a professional basketball player who currently plays for the Chicago Bulls of the National Basketball Association (NBA). He played college basketball for the University of Florida, and was a member of the Florida Gators' starting five that won two consecutive NCAA Men's Division I Basketball Tournaments in 2006 and 2007. In 2014, Noah won the NBA Defensive Player of the Year Award. His grandfather Zacharie Noah was a Cameroonian professional soccer player, winner of the Coupe de France in 1961. His father Yannick Noah is a former N°1 tennis player, winner of the French Open Roland Garros in 1983.

Roberta Cleopatra Flack is an American singer, and musician who is notable for jazz, Pop, R&B, and folk music. She is best known for her classic #1 singles "The First Time Ever I Saw Your Face", "Killing Me Softly with His Song", and "Feel Like Makin' Love"; and for "Where Is the Love" and "The Closer I Get to You", two of her many duets with the late Donny Hathaway. Flack was the first to win the Grammy Award for Record of the Year two consecutive times. According to a DNA analysis, she descended, mainly, from people of Cameroon.

Condoleezza Rice is an American political scientist and diplomat. She served as the 66th United States Secretary of State, and was the second person to hold that office in the administration of President George W. Bush. Rice was the first female African-American secretary of state, as well as the second African American secretary of state, and the second female secretary of state. Rice was President Bush's National Security Advisor during his first term, making her the first woman to serve in that position. Condoleezza Rice mtDNA is traced back to the Tikar people of Cameroon.

Leslie "Les" Payne is a Pulitzer Prize-winning American journalist. He served as an editor and columnist at Newsday and is a founder of the National Association of Black Journalists. According to DNA analysis, he is descended in part from people from Cameroon.

Vanessa Lynn Williams is an American singer, actress, producer and former fashion model. In 1983, she became the first African-American woman crowned Miss America. She earned multiple Grammy, Emmy, and Tony Award nominations. She is arguably the most successful Miss America winner in the field of entertainment. According to DNA test, a portion of her ancestry is from Cameroon.

Cyrus Berenice Kouandjio is a Cameroonian-born American football offensive lineman for the Buffalo Bills of the National Football League (NFL). He was drafted by the Bills in 2014 NFL Draft. Kouandjio ended the 2012 season ranked as the top offensive tackle from the 2011 recruiting class.

Nicolas Batum est un joueur français de basket-ball évoluant aux postes d'arrière et d'ailier pour les Trail Blazers de Portland en NBA. Avec l'équipe de France, il est médaillé d'argent lors du championnat d'Europe 2011 en Lituanie et médaillé d'or au championnat d'Europe 2013 en Slovénie. Nicolas Batum est le fils de Richard Batum, joueur professionnel de basket-ball d'origine camerounaise.

Yaphet Frederick Kotto is an American actor, known for numerous film roles, as well as starring in the NBC television series Homicide: Life on the Street (1993–1999) as Lieutenant Al Giardello. His films include the science-fiction/horror film Alien (1979), and the science-fiction/action film The Running Man. He portrayed the main villain Dr. Kananga/Mr. Big in the James Bond movie Live and Let Die (1973). He appeared opposite Robert De Niro in the comedy thriller Midnight Run (1988) as FBI agent Alonzo Moseley. His father was Avraham Kotto (originally named Njoki Manga Bell), a businessman from Cameroon who immigrated to the United States in the 1920s. Kotto great-grandfather, Alexander Duala Manga Bell, ruled the Douala region of Cameroon in the late-19th century.